解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Renal transplantation represents the treatment of choice of end-stage kidney disease. Delayed graft function (DGF) remains the most frequent complication after this procedure, reaching more than 30%. Its prevention is essential as it impedes early- and long-term prognosis of transplantation. Numerous pharmac...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2597-4
更新日期:2018-04-17 00:00:00
abstract:BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes paralysis of limb, swallowing, and breathing muscles. Riluzole, the Food and Drug Administration-approved drug for ALS, provides minimal benefit, prolonging patient life by only 2-3 months. Previous studies have found a neur...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2557-z
更新日期:2018-04-13 00:00:00
abstract:BACKGROUND:Autism spectrum disorder (ASD) is found in approximately 1% of the population and includes core symptoms that affect general and social development. Beside these core symptoms, it is suggested that up to 60% of children with ASD suffer from comorbid anxiety disorders which may further affect educational, soc...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2591-x
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:Non-retention of participants seriously affects the credibility of clinical trial results and significantly reduces the potential of a trial to influence clinical practice. Non-retention can be defined as instances where participants leave the study prematurely. Examples include withdrawal of consent and los...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2572-0
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:The high co-morbidity of mental disorders, particularly depression, with non-communicable diseases (NCDs) such as cardiovascular disease (CVD), is concerning given the rising burden of NCDs globally, and the role depression plays in confounding prevention and treatment of NCDs. The objective of this randomis...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2518-6
更新日期:2018-03-22 00:00:00
abstract:BACKGROUND:PaVOS is a randomized controlled trial (RCT) which aims to address the use of whole-body vibration exercise (WBV) in combination with parathyroid hormone 1-34 fragment teriparatide (PTH 1-34) treatment in patients with osteoporosis. PTH 1-34 is an effective but expensive anabolic treatment for osteoporosis. ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2551-5
更新日期:2018-03-16 00:00:00
abstract:BACKGROUND:The Pneumatic CompREssion for Preventing VENous Thromboembolism (PREVENT) trial evaluates the effect of adjunctive intermittent pneumatic compression (IPC) with pharmacologic thromboprophylaxis compared to pharmacologic thromboprophylaxis alone on venous thromboembolism (VTE) in critically ill adults. METHO...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2534-6
更新日期:2018-03-15 00:00:00
abstract:BACKGROUND:Practicing activities improves recovery after stroke, but many people in hospital do little activity. Feedback on activity using an accelerometer is a potential method to increase activity in hospital inpatients. This study's goal is to investigate the effect of feedback, enabled by a Smart watch, on daily p...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2476-z
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:Physical exercise interventions have been extensively advocated for the treatment of obesity; however, clinical trials evaluating the effectiveness of exercise interventions on weight control show controversial results. Compensatory mechanisms through a decrease in energy expenditure and/or an increase in ca...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2445-6
更新日期:2018-03-07 00:00:00
abstract:BACKGROUND:For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is unclear whether starting antiplatelet drugs results in an increase in the...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2542-6
更新日期:2018-03-05 00:00:00
abstract:BACKGROUND:Subacromial impingement syndrome (SIS) is a painful, and often long lasting, shoulder condition affecting patient function and quality of life. In a recent study, we observed major strength impairments in shoulder external rotation and abduction (~30%) in a population of patients with pronounced and long-las...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2509-7
更新日期:2018-03-02 00:00:00
abstract:BACKGROUND:Cesarean delivery has already become a very common method of delivery around the world, especially in low-income countries. Hypertrophic scars and wound infections have affected younger mothers and frustrated obstetricians for a long time. Mesenchymal stem cells (MSCs) have strong potential for self-renewal ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2478-x
更新日期:2018-03-02 00:00:00
abstract:BACKGROUND:Exercise-based cardiac rehabilitation is a beneficial therapy for patients with chronic heart failure. The delivery of exercise-based cardiac rehabilitation should adopt an evidence-based approach, as well as be culturally appropriate and sensitive to individual needs and preferences. The Baduanjin Eight-Sil...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2531-9
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Evidence increases that a high or a standard dose of tranexamic acid (TA) reduces postpartum bleeding. The TRACES pharmacobiological substudy aims to establish a therapeutic strategy in hemorrhagic (H) Cesarean section (CS) with respect to the intensity of fibrinolysis by using innovative assays. METHOD/DES...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-017-2421-6
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Severe thrombocytopenia should be corrected by prophylactic platelet transfusion prior to central venous catheter (CVC) insertion, according to national and international guidelines. Even though correction is thought to prevent bleeding complications, evidence supporting the routine administration of prophyl...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2480-3
更新日期:2018-02-20 00:00:00
abstract::Evidence-based treatment for pregnant women will ultimately require research conducted in the population of pregnant women. Currently, few scholars have addressed the issue of responsible inclusion of pregnant women in drug research. Because of additional risks associated with including pregnant women in drug research...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2495-9
更新日期:2018-02-20 00:00:00
abstract:BACKGROUND:During the last decade, the use of ministernotomy in cardiac surgery has increased. Quality of life and patient satisfaction after ministernotomy have never been compared to conventional full sternotomy in randomised trials. The aim of the study is to determine if this minimally invasive approach improves qu...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2486-x
更新日期:2018-02-17 00:00:00
abstract:BACKGROUND:Recognizing the value of promoting public access to clinical trial protocols, Trials pioneered the way for their publication over a decade ago. However, despite major advances in the public accessibility of information about trial methods and results, protocol sharing remains relatively rare. MAIN BODY:Prot...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-018-2510-1
更新日期:2018-02-17 00:00:00
abstract:BACKGROUND:Patients admitted to intensive care units (ICU) with acute respiratory failure (ARF) face chronic complications that can impede return to normal daily function. A mobile, collaborative critical care model may enhance the recovery of ARF survivors. METHODS:The Mobile Critical Care Recovery Program (m-CCRP) s...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2449-2
更新日期:2018-02-07 00:00:00
abstract:BACKGROUND:Compulsory submission of a checklist from the relevant reporting guideline is one of the most widespread journal requirements aiming to improve completeness of reporting. However, the current suboptimal levels of adherence to reporting guidelines observed in the literature may indicate that this journal poli...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2475-0
更新日期:2018-01-29 00:00:00
abstract:BACKGROUND:Research has shown that recruitment to trials is a process that stretches from identifying potentially eligible patients, through eligibility assessment, to obtaining informed consent. The length and complexity of this pathway means that many patients do not have the opportunity to consider participation. Th...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-017-2413-6
更新日期:2018-01-19 00:00:00
abstract:BACKGROUND:Whiplash-associated disorders (WAD) are an enormous and costly burden to Australian society. Up to 50% of people who experience a whiplash injury will never fully recover. Whiplash is resistant to treatment and no early management approach has yet been shown to prevent chronic pain. The early presence of cen...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2450-9
更新日期:2018-01-17 00:00:00
abstract:BACKGROUND:There is currently an absence of high-grade evidence regarding the treatment of chronic sciatica (CS). Whilst gabapentin (GBP) and pregabalin (PGB) are both currently used to treat CS, equipoise exists regarding their individual use. In particular, no head-to-head study of GBP and PGB in CS exists. Despite e...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-017-2400-y
更新日期:2018-01-09 00:00:00
abstract:BACKGROUND:Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimize recovery of patients with traumatic brain injury (TBI). The aim of this study is to evaluate inhibitory attentional control after 18 sessions of active LLLT and compare with the placebo group (sham LLLT). O...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-017-2414-5
更新日期:2018-01-08 00:00:00
abstract:BACKGROUND:Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for postoperative respiratory depression at the doses required for effective analgesia currently limits its clinical use. The use of a low-dos...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-017-2370-0
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:Diabetic distal symmetric polyneuropathy (DSPN) is one of the most common microvascular complications of diabetes mellitus, and it has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and disability rate. The current medications for DSPN are not entirel...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-017-2345-1
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:Fimasartan is the ninth angiotensin receptor blocker to be developed. However, it has not yet been evaluated for reno-protective effects in hypertensive diabetic chronic kidney disease (CKD). The target blood pressure (BP) for hypertensive diabetic CKD is also a controversial topic. This trial was designed t...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-017-2375-8
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:The oversight and conduct of a randomised controlled trial involves several stakeholders, including a Trial Steering Committee (TSC), Trial Management Group (TMG), Data Monitoring Committee (DMC), funder and sponsor. We aimed to examine how the relationships between these stakeholders affect the trial oversi...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-017-2305-9
更新日期:2017-12-22 00:00:00
abstract:BACKGROUND:The evidence base to assess the efficacy and effectiveness of alcohol brief interventions (ABI) is weakened by variation in the outcomes measured and by inconsistent reporting. The 'Outcome Reporting in Brief Intervention Trials: Alcohol' (ORBITAL) project aims to develop a core outcome set (COS) and reporti...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-017-2335-3
更新日期:2017-12-22 00:00:00
abstract:BACKGROUND:Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery. POAF is associated with increased morbidity and hospital costs. We herein describe the protocol for a randomized controlled trial to determine if performing a posterior left pericardiotomy prevents POAF after cardiac...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-2334-4
更新日期:2017-12-13 00:00:00
abstract:BACKGROUND:Delirium is a highly prevalent and morbid syndrome in intensive care units (ICUs). Changing the stressful environment within the ICU via music may be an effective and a scalable way to reduce the burden of delirium. METHODS/DESIGN:The Decreasing Delirium through Music (DDM) study is a three-arm, single-blin...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-2324-6
更新日期:2017-11-29 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease (CKD) exhibit increased morbidity and mortality which is associated with an increased systemic inflammatory burden. Identifying and managing comorbid diseases that contribute to this load may inform novel care pathways that could have a beneficial impact on the morbidity/...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-2236-5
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:Spontaneous recovery from articular cartilage injury is difficult, and the ongoing progression of disease can eventually lead to osteoarthritis. Currently, there is no effective non-surgical treatment for articular cartilage injury. Arthroscopic debridement and microfracture surgery are performed for fibroca...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-2251-6
更新日期:2017-11-06 00:00:00
abstract:BACKGROUND:Biomass fuel smoke is a leading risk factor for the burden of disease worldwide. International campaigns are promoting the widespread adoption of liquefied petroleum gas (LPG) in resource-limited settings. However, it is unclear if the introduction and use of LPG stoves, in settings where biomass fuels are u...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-2179-x
更新日期:2017-11-03 00:00:00
abstract:BACKGROUND:Inconsistent outcome reporting is one significant hurdle to combining results from trials into systematic reviews. Core outcome sets (COS) can reduce this barrier. The aim of this review was to map outcomes reported in caries prevention and management randomised controlled trials (RCT) as a first step to COS...
journal_title:Trials
pub_type: 杂志文章,评审
doi:10.1186/s13063-017-2256-1
更新日期:2017-11-02 00:00:00
abstract:BACKGROUND:Meta-analyses of randomized controlled trials (RCTs) have shown that exercise has beneficial effects on quality of life (QoL) in patients with breast cancer. However, these effects were often small. Blinding in an exercise trial is not possible, which has the possible disadvantage of difficult accrual, drop-...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-2252-5
更新日期:2017-10-27 00:00:00
abstract:BACKGROUND:Oxygen is a life-saving, essential medicine that is important for the treatment of many common childhood conditions. Improved oxygen systems can reduce childhood pneumonia mortality substantially. However, providing oxygen to children is challenging, especially in small hospitals with weak infrastructure and...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-2241-8
更新日期:2017-10-27 00:00:00
abstract:BACKGROUND:Basal cell carcinoma is the most common skin cancer worldwide. Treatment options include both surgical and topical modalities. Although risk of metastasis is low, basal cell carcinoma can be invasive and infiltrate important underlying structures such as bone or cartilage. While many clinical trials examinin...
journal_title:Trials
pub_type: 共识发展会议,杂志文章
doi:10.1186/s13063-017-2244-5
更新日期:2017-10-23 00:00:00
abstract:BACKGROUND:Intellectual disability (ID) is characterized by limitations in intellectual functioning and adaptive behavior. Adults with ID exhibit higher rates of obesity and poorer health status compared to the general population. Continuity of care and barriers to health-related activities may contribute to the poorer...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-2239-2
更新日期:2017-10-23 00:00:00
abstract:BACKGROUND:Chronic subdural hematoma (cSDH) is one of the most common conditions encountered in neurosurgical practice. Recurrence, observed in 5-30% of patients, is a major clinical problem. The temperature of the irrigation fluid used during evacuation of the hematoma might theoretically influence recurrence rates si...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13063-017-2194-y
更新日期:2017-10-11 00:00:00